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KMID : 1189420070200030107
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 3 p.107 ~ p.117
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Effects of Kumsooyukkun-jeon extract on the Ovalbumin-Induced Allergic Asthma in Mice
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Zo Zoon-Ki
Ahn Chan-Gn
Kim Kyung-Jun
Kim Nam-Kwen
Park Min-Cheol
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Abstract
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Objective: Kumsoouyukkun-joen extract(KSE) has been used treating asthma for a long time in korea. In the present study, I examined the effects of KSE on the ovalbumin(OVA)-induced airway hyper-reactivity(AHR).
Methods: To examine the effects of KSE on asthma, mice were sensitized with of OVA and 1 mg of aluminum potassium sulfate(Alum; Sigma)intraperitoneally on day 0 and 7. On day 14, mice were challenged on 3 consecutive days with 5% OVA and AHR was assessed 24 hrs after the last challenge. To examine severity of AHR, I examined eosinophil population and cytokine production in bronchoaveloar lavage fluid(BALF) and stained with hematoxylin and eosin in lung and also measured enhanced pause(Penh) in AHR from mice.
Results and Conclusion: KSE potently inhibited the development of Penh and also reduced the number of eosinophil during OVA-induced AHR. KSE also inhibited cytokines production such as IL-4, IL-5 in BALF. Furthermore, KSE inhibited percentage of eosinophil in BALF. These results suggest that KSE may be beneficial oriental medicine for AHR.
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KEYWORD
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asthma, Kumsoouyukkun-joen, airwayhyper-reactivity, eosinophil
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